John Constantine (Keanu Reeves) is a dying anti-hero battling supernatural forces in a desperate attempt to earn his way into Heaven after having already been condemned to Hell. He crosses paths with police officer Angela Dodson (Rachel Weisz), who is grieving for her twin Isobel, the victim of an apparent suicide. As the two uncover the mystery behind Isobel’s death, they discover a battle between the forces of Heaven and Hell beyond either’s imagination, and Constantine uncovers the secret to his own redemption.