Earth in the future is populated by vampires at every corner. However, their supply of blood is about to run out when man faces extinction. Most of the population is now members of the undead. As humans are disappearing the vampires plan to capture the remaining population in order to farm them and ensure their food supply is safe. As a backup plan they are trying to find a blood substitute to feed their needs. Hematologist, Edward Dalton (Ethan Hawke) is in charge of the research project. He finds some of the last humans alive. The humans are led by Elvis (William Defoe) who was once a vampire. Elvis’ past may hold the solution that could save the human race. Dalton has to avoid his boss’ (Sam Neill) security team while pursuing his own agenda. The boss however, wants to find the blood substitute and repopulate the human race and sell their blood to the highest bidder.